Gypenosides Protected the Neural Stem Cells in the Subventricular Zone of Neonatal Rats that Were Prenatally Exposed to EthanolReportar como inadecuado




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1

Department of Cell Biology, School of Medicine, Shandong University, Jinan 250012, China

2

Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan 250012, China





*

Author to whom correspondence should be addressed.



Abstract Fetal alcohol spectrum disorder FASD can cause severe mental retardation in children who are prenatally exposed to ethanol. The effects of prenatal and early postnatal ethanol exposure on adult hippocampal neurogenesis have been investigated; however, the effects of prenatal ethanol exposure on the subventricular zone SVZ have not. Gypenosides GPs have been reported to have neuroprotective effects in addition to other bioactivities. The effects of GPs on neural stem cells NSCs in the FASD model are unknown. Here, we test the effect of prenatal ethanol exposure on the neonatal SVZ, and the protection potential of GPs on NSCs in FASD rats. Our results show that prenatal ethanol exposure can suppress the cell proliferation and differentiation of neural stem cells in the neonatal SVZ and that GPs 400 mg-kg-day can significantly increase the cell proliferation and differentiation of neural stem cells inhibited by ethanol. Our data indicate that GPs have neuroprotective effects on the NSCs and can enhance the neurogenesis inhibited by ethanol within the SVZ of neonatal rats. These findings provide new evidence for a potential therapy involving GPs for the treatment of FASD. View Full-Text

Keywords: subventricular zone; cell proliferation; gypenosides; fetal alcohol spectrum disorder subventricular zone; cell proliferation; gypenosides; fetal alcohol spectrum disorder





Autor: Lun Dong 1,2, Kun-Qi Yang 1, Wen-Yan Fu 1, Zhen-Hua Shang 1, Qing-Yu Zhang 1, Fang-Miao Jing 1, Lin-Lin Li 1, Hua Xin 1 and Xiao-Jing Wang 1,*

Fuente: http://mdpi.com/



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