Prenatal Exposure to Arsenic and Cadmium Impacts Infectious Disease-Related Genes within the Glucocorticoid Receptor Signal Transduction PathwayReportar como inadecuado




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1

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, CB 7431, Chapel Hill, NC 27599, USA

2

Curriculum in Toxicology, School of Medicine, University of North Carolina, 104 Mason Farm Road, CB 7310, Chapel Hill, NC 27599, USA



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract There is increasing evidence that environmental agents mediate susceptibility to infectious disease. Studies support the impact of prenatal-early life exposure to the environmental metals inorganic arsenic iAs and cadmium Cd on increased risk for susceptibility to infection. The specific biological mechanisms that underlie such exposure-mediated effects remain understudied. This research aimed to identify key genes-signal transduction pathways that associate prenatal exposure to these toxic metals with changes in infectious disease susceptibility using a Comparative Genomic Enrichment Method CGEM. Using CGEM an infectious disease gene IDG database was developed comprising 1085 genes with known roles in viral, bacterial, and parasitic disease pathways. Subsequently, datasets collected from human pregnancy cohorts exposed to iAs or Cd were examined in relationship to the IDGs, specifically focusing on data representing epigenetic modifications 5-methyl cytosine, genomic perturbations mRNA expression, and proteomic shifts protein expression. A set of 82 infection and exposure-related genes was identified and found to be enriched for their role in the glucocorticoid receptor signal transduction pathway. Given their common identification across numerous human cohorts and their known toxicological role in disease, the identified genes within the glucocorticoid signal transduction pathway may underlie altered infectious disease susceptibility associated with prenatal exposures to the toxic metals iAs and Cd in humans. View Full-Text

Keywords: arsenic; cadmium; environmental toxicant; epigenome; genome; glucocorticoid receptor; infectious disease; in utero; pathway; signal transduction arsenic; cadmium; environmental toxicant; epigenome; genome; glucocorticoid receptor; infectious disease; in utero; pathway; signal transduction





Autor: Julia E. Rager 1,†, Andrew Yosim 1,† and Rebecca C. Fry 1,2,*

Fuente: http://mdpi.com/



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