Vanadium Compounds as Pro-Inflammatory Agents: Effects on CyclooxygenasesReportar como inadecuado




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1

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland

2

Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24 Str., 71-460 Szczecin, Poland



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Kaixun Huang

Abstract This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate orthovanadate, vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases PTP, epidermal growth factor receptor EGFR, PLCγ, Src, mitogen-activated protein kinase MAPK cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds. View Full-Text

Keywords: vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase





Autor: Jan Korbecki 1, Irena Baranowska-Bosiacka 1,* , Izabela Gutowska 2,† and Dariusz Chlubek 1,†

Fuente: http://mdpi.com/



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