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1

Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310-UTM Skudai, Johor, Malaysia

2

Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310-UTM Skudai, Johor, Malaysia





*

Author to whom correspondence should be addressed.



Academic Editor: Fan-Gang Tseng

Abstract Electrical properties of living cells have been proven to play significant roles in understanding of various biological activities including disease progression both at the cellular and molecular levels. Since two decades ago, many researchers have developed tools to analyze the cell’s electrical states especially in single cell analysis SCA. In depth analysis and more fully described activities of cell differentiation and cancer can only be accomplished with single cell analysis. This growing interest was supported by the emergence of various microfluidic techniques to fulfill high precisions screening, reduced equipment cost and low analysis time for characterization of the single cell’s electrical properties, as compared to classical bulky technique. This paper presents a historical review of single cell electrical properties analysis development from classical techniques to recent advances in microfluidic techniques. Technical details of the different microfluidic techniques are highlighted, and the advantages and limitations of various microfluidic devices are discussed. View Full-Text

Keywords: conversional patch clamp; electrical properties; electrorotation; impedance flow cytometry; microelectrical impedance spectroscopy µEIS; single cell analysis SCA conversional patch clamp; electrical properties; electrorotation; impedance flow cytometry; microelectrical impedance spectroscopy µEIS; single cell analysis SCA





Autor: Muhammad Asraf Mansor 1 and Mohd Ridzuan Ahmad 2,*

Fuente: http://mdpi.com/



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