Angiotensin-I Converting Enzyme ACE Inhibitory and Anti-Oxidant Activities of Sea Cucumber Actinopyga lecanora HydrolysatesReportar como inadecuado




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1

Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2

Department of Food Science and Technology, College of Agriculture and Natural Resources, Islamic Azad University, Sanandaj 66131, Iran

3

Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia





*

Author to whom correspondence should be addressed.



Academic Editor: Maurizio Battino

Abstract In recent years, food protein-derived hydrolysates have received considerable attention because of their numerous health benefits. Amongst the hydrolysates, those with anti-hypertensive and anti-oxidative activities are receiving special attention as both activities can play significant roles in preventing cardiovascular diseases. The present study investigated the angiotensin-I converting enzyme ACE inhibitory and anti-oxidative activities of Actinopyga lecanora A. lecanora hydrolysates, which had been prepared by alcalase, papain, bromelain, flavourzyme, pepsin, and trypsin under their optimum conditions. The alcalase hydrolysate showed the highest ACE inhibitory activity 69.8% after 8 h of hydrolysis while the highest anti-oxidative activities measured by 2,2-diphenyl 1-1-picrylhydrazyl radical scavenging DPPH 56.00% and ferrous ion-chelating FIC 59.00% methods were exhibited after 24 h and 8 h of hydrolysis, respectively. The ACE-inhibitory and anti-oxidative activities displayed dose-dependent trends, and increased with increasing protein hydrolysate concentrations. Moreover, strong positive correlations between angiotensin-I converting enzyme ACE inhibitory and anti-oxidative activities were also observed. This study indicates that A. lecanora hydrolysate can be exploited as a source of functional food owing to its anti-oxidant as well as anti-hypertension functions. View Full-Text

Keywords: Actinopyga lecanora; anti-oxidative; ACE inhibitory Actinopyga lecanora; anti-oxidative; ACE inhibitory





Autor: Raheleh Ghanbari 1, Mohammad Zarei 1,2, Afshin Ebrahimpour 1, Azizah Abdul-Hamid 1, Amin Ismail 3 and Nazamid Saari 1,*

Fuente: http://mdpi.com/



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