Intravenous Administration of Cilostazol Nanoparticles Ameliorates Acute Ischemic Stroke in a Cerebral Ischemia-Reperfusion-Induced Injury ModelReportar como inadecuado




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Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan





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Academic Editor: Bing Yan

Abstract It was reported that cilostazol CLZ suppressed disruption of the microvasculature in ischemic areas. In this study, we have designed novel injection formulations containing CLZ nanoparticles using 0.5% methylcellulose, 0.2% docusate sodium salt, and mill methods CLZnano dispersion; particle size 81 ± 59 nm, mean ± S.D., and investigated their toxicity and usefulness in a cerebral ischemia-reperfusion-induced injury model MCAO-reperfusion mice. The pharmacokinetics of injections of CLZnano dispersions is similar to that of CLZ solutions prepared with 2-hydroxypropyl-β-cyclodextrin, and no changes in the rate of hemolysis of rabbit red blood cells, a model of cell injury, were observed with CLZnano dispersions. In addition, the intravenous injection of 0.6 mg-kg CLZnano dispersions does not affect the blood pressure and blood flow, and the 0.6 mg-kg CLZnano dispersions ameliorate neurological deficits and ischemic stroke in MCAO-reperfusion mice. It is possible that the CLZnano dispersions will provide effective therapy for ischemic stroke patients, and that injection preparations of lipophilic drugs containing drug nanoparticles expand their therapeutic usage. View Full-Text

Keywords: cilostazol; ischemic stroke; injection formulation; nanoparticles; pharmacokinetics cilostazol; ischemic stroke; injection formulation; nanoparticles; pharmacokinetics





Autor: Noriaki Nagai, Chiaki Yoshioka, Yoshimasa Ito * , Yoshinori Funakami, Hiroyuki Nishikawa and Atsufumi Kawabata

Fuente: http://mdpi.com/



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