Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloriaReportar como inadecuado




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1

Crop Environment Section, Hualien District Agricultural Research and Extension Station, Hualien 973, Taiwan

2

Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan

3

Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Gopinadhan Paliyath

Abstract Camellia tenuifloria is an indigenous Camellia species used for the production of camellia oil in Taiwan. This study investigated for the first time the potential antioxidant, anti-tyrosinase and anti-inflammatory activities of oil production byproducts, specifically those of the fruit shell, seed shell, and seed pomace from C. tenuifloria. It was found that the crude ethanol extract of the seed shell had the strongest DPPH scavenging and mushroom tyrosinase inhibitory activities, followed by the fruit shell, while seed pomace was the weakest. The IC50 values of crude extracts and fractions on monophenolase were smaller than diphenolase. The phenolic-rich methanol fraction of seed shell SM reduced nitric oxide NO production, and inducible nitric oxide synthase iNOS expression in lipopolysaccharide LPS-stimulated RAW 264.7 cells. It also repressed the expression of IL-1β, and secretion of prostaglandin E2 PGE2 and IL-6 in response to LPS. SM strongly stimulated heme oxygenase 1 HO-1 expression and addition of zinc protoporphyrin ZnPP, a HO-1 competitive inhibitor, reversed the inhibition of NO production, indicating the involvement of HO-1 in its anti-inflammatory activity. The effects observed in this study provide evidence for the reuse of residues from C. tenuifloria in the food additive, medicine and cosmetic industries. View Full-Text

Keywords: Camellia tenuifloria ; monophenolase; diphenolase; iNOS; macrophages Camellia tenuifloria ; monophenolase; diphenolase; iNOS; macrophages





Autor: Shu-Yuan Chiou 1,†, Choi-Lan Ha 2,†, Pei-Shan Wu 3, Chiu-Ling Yeh 3, Ying-Shan Su 2, Man-Po Li 3 and Ming-Jiuan Wu 3,*

Fuente: http://mdpi.com/



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