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1

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea

2

Office of Research Affairs, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03720, Korea

3

College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Katalin Prokai-Tatrai

Abstract The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier BBB. They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments. View Full-Text

Keywords: selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier BBB selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier BBB





Autor: Yong-Sung Choi 1, Dong-Myung Kim 2, Yoon-Jung Kim 1, Sai Yang 1, Kyung-Tae Lee 3, Jong Hoon Ryu 3 and Jin-Hyun Jeong 1,*

Fuente: http://mdpi.com/



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