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Natural Products and Industrial Biochemistry Research Group NPIB, Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam

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Microbial Processes and Interactions MiPI, Agro-biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium

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Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam

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Food technology and Formulation, Agro-Biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium





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Academic Editor: Marianne Su-Ling Brooks

Abstract The literature presents a growing body of evidence demonstrating the positive effect of probiotics on health. Probiotic consumption levels are rising quickly in the world despite the fluctuation of their viability and functionality. Technological methods aiming at improving probiotic characteristics are thus highly wanted. However, microbial metabolic engineering toolbox is not available for this kind of application. On the other hand, basic microbiology teaches us that bacteria are able to exhibit adaptation to external stresses. It is known that adequately applied sub-lethal stress, i.e., controlled in amplitude and frequency at a given stage of the culture, is able to enhance microbial robustness. This property could be potentially used to improve the viability of probiotic bacteria, but some technical challenges still need to be overcome before any industrial implementation. This review paper investigates the different technical tools that can be used in order to define the proper condition for improving viability of probiotic bacteria and their implementation at the industrial scale. Based on the example of Bifidobacterium bifidum, potentialities for simultaneously improving viability, but also functionality of probiotics will be described. View Full-Text

Keywords: biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness





Autor: Huu-Thanh Nguyen 1,2,* , Dieu-Hien Truong 3, Sonagnon Kouhoundé 2, Sokny Ly 2, Hary Razafindralambo 4 and Frank Delvigne 2,*

Fuente: http://mdpi.com/



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