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1

Tianjin Key Laboratory of Animal and Plant Resistance-College of Life Sciences, Tianjin Normal University, Tianjin 300387, China

2

Tianjin Aquatic Animal Infectious Disease Control and Prevention Center, Tianjin 300221, China





*

Author to whom correspondence should be addressed.



Academic Editor: Tatyana Karabencheva-Christova

Abstract The protein-protein interaction network PIN is a useful tool for systematic investigation of the complex biological activities in the cell. With the increasing interests on the proteome-wide interaction networks, PINs have been reconstructed for many species, including virus, bacteria, plants, animals, and humans. With the development of biological techniques, the reconstruction methods of PIN are further improved. PIN has gradually penetrated many fields in biological research. In this work we systematically reviewed the development of PIN in the past fifteen years, with respect to its reconstruction and application of function annotation, subsystem investigation, evolution analysis, hub protein analysis, and regulation mechanism analysis. Due to the significant role of PIN in the in-depth exploration of biological process mechanisms, PIN will be preferred by more and more researchers for the systematic study of the protein systems in various kinds of organisms. View Full-Text

Keywords: protein–protein interaction network; reconstruction technique; interactome; proteome protein–protein interaction network; reconstruction technique; interactome; proteome





Autor: Tong Hao 1, Wei Peng 1, Qian Wang 1, Bin Wang 1 and Jinsheng Sun 1,2,*

Fuente: http://mdpi.com/



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