Elevated Preoperative Serum Alanine Aminotransferase-Aspartate Aminotransferase ALT-AST Ratio Is Associated with Better Prognosis in Patients Undergoing Curative Treatment for Gastric AdenocarcinomaReportar como inadecuado




Elevated Preoperative Serum Alanine Aminotransferase-Aspartate Aminotransferase ALT-AST Ratio Is Associated with Better Prognosis in Patients Undergoing Curative Treatment for Gastric Adenocarcinoma - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: William Chi-shing Cho

Abstract The level of anine aminotransferase-aspartate aminotransferase ALT-AST ratio in the serum was often used to assess liver injury. Whether the ALT-AST ratio LSR was associated with prognosis for gastric adenocarcinoma GA has not been reported in the literature. Our aim was to investigate the prognostic value of the preoperative LSR in patients with GA. A retrospective study was performed in 231 patients with GA undergoing curative resection. The medical records collected include clinical information and laboratory results. We investigated the correlations between the preoperative LSR and overall survival OS. Survival analysis was conducted with the Kaplan–Meier method, and Cox regression analysis was used to determine significant independent prognostic factors for predicting survival. A p value of <0.05 was considered to be statistically significant. A total of 231 patients were finally enrolled. The median overall survival was 47 months. Multivariate analysis indicated that preoperative LSR was an independent prognostic factor in GA. Patients with LSR ≤ 0.80 had a greater risk of death than those with LSR > 0.80. The LSR was independently associated with OS in patients with GA hazard ratio: 0.610; 95% confidence interval: 0.388–0.958; p = 0.032, along with tumor stages hazard ratio: 3.118; 95% confidence interval: 2.044–4.756; p < 0.001 and distant metastases hazard ratio: 1.957; 95% confidence interval: 1.119–3.422; p = 0.019. Our study first established a connection between the preoperative LSR and patients undergoing curative resection for GA, suggesting that LSR was a simple, inexpensive, and easily measurable marker as a prognostic factor, and may help to identify high-risk patients for treatment decisions. View Full-Text

Keywords: ALT-AST ratio LSR; gastric adenocarcinoma; survival; prognosis ALT-AST ratio LSR; gastric adenocarcinoma; survival; prognosis





Autor: Shu-Lin Chen †, Jian-Pei Li †, Lin-Fang Li, Tao Zeng and Xia He *

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados