The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn InjuryReportar como inadecuado


The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury


The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia

2

Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia





*

Author to whom correspondence should be addressed.



Abstract Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of γδ T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response. View Full-Text

Keywords: burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines





Autor: Albert Kim 1,* , Thomas Lang 1, Meilang Xue 2, Aruna Wijewardana 1, Chris Jackson 2 and John Vandervord 1

Fuente: http://mdpi.com/



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