Translocator Protein-18 kDa TSPO Positron Emission Tomography PET Imaging and Its Clinical Impact in Neurodegenerative DiseasesReportar como inadecuado




Translocator Protein-18 kDa TSPO Positron Emission Tomography PET Imaging and Its Clinical Impact in Neurodegenerative Diseases - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

CHRU Tours, 2 Boulevard Tonnellé, 37044 Tours, France

2

Institut National de la Santé et de la Recherche Médicale U930, 10 Boulevard Tonnellé, 37032 Tours, France





*

Author to whom correspondence should be addressed.



Academic Editor: Styliani-Anna E. Tsirka

Abstract In vivo exploration of activated microglia in neurodegenerative diseases is achievable by Positron Emission Tomography PET imaging, using dedicated radiopharmaceuticals targeting the translocator protein-18 kDa TSPO. In this review, we emphasized the major advances made over the last 20 years, thanks to TSPO PET imaging, to define the pathophysiological implication of microglia activation and neuroinflammation in neurodegenerative diseases, including Parkinson’s disease, Huntington’s disease, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and also in psychiatric disorders. The extent and upregulation of TSPO as a molecular biomarker of activated microglia in the human brain is now widely documented in these pathologies, but its significance, and especially its protective or deleterious action regarding the disease’s stage, remains under debate. Thus, we exposed new and plausible suggestions to enhance the contribution of TSPO PET imaging for biomedical research by exploring microglia’s role and interactions with other cells in brain parenchyma. Multiplex approaches, associating TSPO PET radiopharmaceuticals with other biomarkers PET imaging of cellular metabolism, neurotransmission or abnormal protein aggregates, but also other imaging modalities, and peripheral cytokine levels measurement and-or metabolomics analysis was considered. Finally, the actual clinical impact of TSPO PET imaging as a routine biomarker of neuroinflammation was put into perspective regarding the current development of diagnostic and therapeutic strategies for neurodegenerative diseases. View Full-Text

Keywords: microglial activation; neuroinflammation; PET; radiopharmaceutical; TSPO; neurodegenerative diseases; psychiatric disorders microglial activation; neuroinflammation; PET; radiopharmaceutical; TSPO; neurodegenerative diseases; psychiatric disorders





Autor: Anne-Claire Dupont 1,2,* , Bérenger Largeau 1, Maria Joao Santiago Ribeiro 1,2, Denis Guilloteau 1,2, Claire Tronel 2 and Nicolas Arlicot 1,2

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados