MMP-2 and 9 in Chronic Kidney DiseaseReportar como inadecuado


MMP-2 and 9 in Chronic Kidney Disease


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1

Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China

2

Department of Nephrology, Zhongda Hospital, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China





*

Author to whom correspondence should be addressed.



Academic Editor: Masatoshi Maki

Abstract Gelatinases are members of the matrix metalloproteinase MMPs family; they play an important role in the degradation of the extracellular matrix ECM. This effect is also crucial in the development and progression of chronic kidney disease CKD. Its expression, as well as its activity regulation are closely related to the cell signaling pathways, hypoxia and cell membrane structural change. Gelatinases also can affect the development and progression of CKD through the various interactions with tumor necrosis factors TNFs, monocyte chemoattractant proteins MCPs, growth factors GFs, oxidative stress OS, and so on. Currently, their non-proteolytic function is a hot topic of research, which may also be associated with the progression of CKD. Therefore, with the in-depth understanding about the function of gelatinases, we can have a more specific and accurate understanding of their role in the human body. View Full-Text

Keywords: gelatinases; matrix metalloproteinase; chronic kidney disease; non-proteolytic function gelatinases; matrix metalloproteinase; chronic kidney disease; non-proteolytic function





Autor: Zhengyuan Cheng 1, Manoj Hang Limbu 1, Zhi Wang 1, Jing Liu 1, Lei Liu 1, Xiaoyi Zhang 1, Pingsheng Chen 1,* and Bicheng Liu 2

Fuente: http://mdpi.com/



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