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Therapeutic Potential of Targeting the Ghrelin Pathway


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1

Institute for Diabetes and Obesity and Helmholtz Diabetes Center, Helmholtz Zentrum München German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany

2

Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany

3

Institute for Diabetes and Obesity IDO, Business Campus Garching-Hochbrück, Parkring 13, 85748 Garching, Germany





*

Author to whom correspondence should be addressed.



Academic Editor: Suzanne L. Dickson

Abstract Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone secretagogue receptor 1a GHSR1a. Since then, ghrelin has been found to exert a plethora of physiological effects that go far beyond its initial characterization as a growth hormone GH secretagogue. Among the numerous well-established effects of ghrelin are the stimulation of appetite and lipid accumulation, the modulation of immunity and inflammation, the stimulation of gastric motility, the improvement of cardiac performance, the modulation of stress, anxiety, taste sensation and reward-seeking behavior, as well as the regulation of glucose metabolism and thermogenesis. Due to a variety of beneficial effects on systems’ metabolism, pharmacological targeting of the endogenous ghrelin system is widely considered a valuable approach to treat metabolic complications, such as chronic inflammation, gastroparesis or cancer-associated anorexia and cachexia. The aim of this review is to discuss and highlight the broad pharmacological potential of ghrelin pathway modulation for the treatment of anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal GI disorders, inflammatory disorders and metabolic syndrome. View Full-Text

Keywords: ghrelin; therapy; pathology; inflammation; anorexia ghrelin; therapy; pathology; inflammation; anorexia





Autor: Gustav Colldén 1, Matthias H. Tschöp 1,2 and Timo D. Müller 1,3,*

Fuente: http://mdpi.com/



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