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1

Section Health and Life Sciences, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

2

Section Health Sciences, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

3

Institute for Environmental Studies, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands





*

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Abstract Growth in the first year of life may already be predictive of obesity later in childhood. The objective was to assess the association between prenatal exposure to various endocrine disrupting chemicals EDCs and child growth during the first year. Dichloro-diphenyldichloroethylene DDE, mono2-ethyl-5-carboxypentylphthalate MECPP, mono2-ethyl-5-hydroxyhexylphthalate MEHHP, mono2-ethyl-5-oxohexylphthalate MEOHP, polychlorinated biphenyl-153, perfluorooctanesulfonic acid, and perfluoro-octanoic acid were measured in cord plasma or breast milk. Data on weight, length, and head circumference HC until 11 months after birth was obtained from 89 mother-child pairs. Mixed models were composed for each health outcome and exposure in quartiles. For MEOHP, boys in quartile 1 had a higher BMI than higher exposed boys p = 0.029. High DDE exposure was associated with low BMI over time in boys 0.8 kg-m2 difference at 11 m. Boys with high MECPP exposure had a greater HC 1.0 cm difference at 11 m than other boys p = 0.047, as did girls in the second quartile of MEHHP p = 0.018 and DDE p < 0.001 exposure. In conclusion, exposure to phthalates and DDE was associated with BMI as well as with HC during the first year after birth. These results should be interpreted with caution though, due to the limited sample size. View Full-Text

Keywords: endocrine disruption; prenatal exposure; BMI; head circumference; early childhood endocrine disruption; prenatal exposure; BMI; head circumference; early childhood





Autor: Marijke de Cock 1,* , Michiel R. de Boer 2, Marja Lamoree 3, Juliette Legler 3 and Margot van de Bor 1

Fuente: http://mdpi.com/



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