Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped VirusesReportar como inadecuado




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1

Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City 32023, Taiwan

2

Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan

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Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan

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Division of General Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, 1492 Zhongshan Road, Taoyuan City 33004, Taiwan





*

Author to whom correspondence should be addressed.



Academic Editor: Huang-Tsung Chang

Abstract The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide GO sheets and GO sheets with silver particles GO-Ag against enveloped and non-enveloped viruses, feline coronavirus FCoV with an envelope and infectious bursal disease virus IBDV without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses. View Full-Text

Keywords: graphene oxide; silver nanoparticle; feline coronavirus; infectious bursal disease virus; enveloped virus; non-enveloped virus graphene oxide; silver nanoparticle; feline coronavirus; infectious bursal disease virus; enveloped virus; non-enveloped virus





Autor: Yi-Ning Chen 1,* , Yi-Huang Hsueh 2, Chien-Te Hsieh 3, Dong-Ying Tzou 3 and Pai-Ling Chang 4

Fuente: http://mdpi.com/



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