Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-AnalysisReportar como inadecuado




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1

Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, 115 Donghu Road, Wuhan 430071, China

2

Global Health Institute, Wuhan University, 115 Donghu Road, Wuhan 430071, China





*

Author to whom correspondence should be addressed.



Academic Editor: Paul B. Tchounwou

Abstract Background: Studies evaluating the association between the atrial natriuretic peptide ANP genetic polymorphism and the risk of essential hypertension EH have reported inconsistent results. The aim of this meta-analysis was to provide a more reliable estimation of the possible relationship between the atrial natriuretic peptide genetic polymorphism and the risk of essential hypertension EH. Methods: Relevant articles were searched to identify all case-control or cohort design studies of the associations between ANP polymorphism and EH. The heterogeneity was checked using the Q test and the inconsistent index I2. The odds ratio OR test and 95% confidence interval CI were calculated in a fixed or random effects model to evaluate the strength of association. Begg’s test and Egger’s test were applied to evaluate the publication bias. Results: A total of 25 case-control studies including 5520 cases and 5210 controls exploring the association between ANP polymorphism and EH were available for this meta-analysis. No significant association between the T2238C polymorphism and overall EH risk under the five genetic models was found C vs. T: OR = 1.1, 95%CI = 0.94–1.2, p = 0.38; TC vs. TT: OR = 1.1, 95%CI = 0.88–1.5, p = 0.32; CC vs. TT: OR = 1.3, 95%CI = 0.90–1.9, p = 0.16; CC + TC vs. TT: OR = 1.1, 95%CI = 0.88–1.4, p = 0.35; CC vs. TT + TC: OR = 1.1, 95%CI = 0.83–1.4, p = 0.55. We also found that the G1837A polymorphism had no significant association with overall EH risk A vs. G: OR = 1.3, 95%CI = 0.96–1.9, p = 0.090; GA vs. GG: OR = 1.5, 95%CI = 0.83–2.6, p = 0.19; AA vs. GG: OR = 0.87, 95%CI = 0.34–2.3, p = 0.78; AA + GA vs. GG: OR = 1.5, 95%CI = 0.86–2.5, p = 0.17; AA vs. GG + GA: OR = 1.3, 95%CI = 0.85–2.0, p = 0.22. In the analysis of the T1766C polymorphism, after removing the study of Nkeh, the 1766C allele suggested a protective effect in the model of TC vs. TT OR = 0.64, 95%CI = 0.47–0.86, p = 0.003 and CC + TC vs. TT OR = 0.64, 95%CI = 0.48–0.87, p = 0.004. Conclusions: This meta-analysis suggested that no significant relationships between ANP T2238C, G1837A gene polymorphisms and the risk of essential hypertension exist. Conversely, the ANP T1766C gene polymorphism may be associated with the risk of essential hypertension, and the 1766C allele may be a protective factor against EH. However, due to the number of limited articles on the T1766C polymorphisms, further studies are still needed to accurately prove the association between the T1766C gene polymorphism and the risk of essential hypertension. View Full-Text

Keywords: ANP; polymorphism; essential hypertension; meta-analysis ANP; polymorphism; essential hypertension; meta-analysis





Autor: Jinyao Wang 1, Zhenkun Wang 1 and Chuanhua Yu 1,2,*

Fuente: http://mdpi.com/



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