Incidence of Myelodysplastic Syndrome in UK Petroleum Distribution and Oil Refinery Workers, 1995–2011Reportar como inadecuado




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Institute of Applied Health Research, College of Medical And Dental Sciences, University of Birmingham, Birmingham B13 9TY, UK





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Academic Editor: Paul Tchounwou

Abstract The incidence of myelodysplastic syndrome MDS experienced by cohorts of 16,467 petroleum distribution workers and 28,554 oil refinery workers has been investigated. Study subjects were all those male employees first employed at one of 476 UK petroleum distribution centres or eight UK oil refineries in the period 1946–1974; all subjects had a minimum of twelve months employment with some employment after 1st January, 1951. Observed numbers Obs of MDS cases were compared with expectations based on national incidence rates for the period 1995–2011. The overall standardised registration ratio SRR was 73 Obs = 17 in petroleum distribution workers for the age-range 15–84 years, and 77 Obs = 21 for the age-range 15–99 years. The overall SRR was 81 Obs = 29 in oil refinery workers for the age-range 15–84 years, and 83 Obs = 36 for the age-range 15–99 years. More detailed analyses were carried out in terms of year of registration, period from hire, decade of hire, and duration of employment. The overall SRR findings did not provide clear evidence for the presence of an occupational cancer hazard, and provide no support for the hypothesis that low-level benzene exposure has an important effect on the risks of MDS. View Full-Text

Keywords: myelodysplastic syndrome; benzene; prospective cohort study myelodysplastic syndrome; benzene; prospective cohort study





Autor: Tom Sorahan * and Nuredin Mohammed

Fuente: http://mdpi.com/



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