In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung FluidsReportar como inadecuado


In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids


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1

Laboratoire Génie Civil et géo-Environnement LGCgE, ISA Lille, Yncréa Hauts-de-France, 48 Boulevard Vauban, Lille Cedex 59046, France

2

British Geological Survey, Keyworth, Nottingham NG12 5GG, UK





*

Author to whom correspondence should be addressed.



Academic Editor: Jose A. Centeno

Abstract An investigation for assessing pulmonary bioaccessibility of metals from reference materials is presented using simulated lung fluids. The objective of this paper was to contribute to an enhanced understanding of airborne particulate matter and its toxic potential following inhalation. A large set of metallic elements Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, and Zn was investigated using three lung fluids phosphate-buffered saline, Gamble’s solution and artificial lysosomal fluid on three standard reference materials representing different types of particle sources. Composition of the leaching solution and four solid-to-liquid S-L ratios were tested. The results showed that bioaccessibility was speciation- i.e., distribution and element-dependent, with percentages varying from 0.04% for Pb to 86.0% for Cd. The higher extraction of metallic elements was obtained with the artificial lysosomal fluid, in which a relative stability of bioaccessibility was observed in a large range of S-L ratios from 1-1000 to 1-10,000. For further investigations, it is suggested that this method be used to assess lung bioaccessibility of metals from smelter-impacted dusts. View Full-Text

Keywords: airborne particulate matter; metallic elements; bioaccessibility; simulated lung fluids airborne particulate matter; metallic elements; bioaccessibility; simulated lung fluids





Autor: Aurélie Pelfrêne 1,* , Mark R. Cave 2, Joanna Wragg 2 and Francis Douay 1

Fuente: http://mdpi.com/



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