25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological StudiesReportar como inadecuado


25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies


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Department of Environmental Health, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, Vienna A-1090, Austria





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Academic Editor: Paul B. Tchounwou

Abstract Epidemiological evidence suggests an association between low vitamin D status and risk for various outcomes including cardiovascular diseases, cancer, and type 2 diabetes mellitus T2DM. Analyzing serum 25-hydroxyvitamin D 25OHD is the most established means to evaluate an individual’s vitamin D status. However, cutoff values for 25OHD insufficiency as well as for optimal 25OHD levels are controversial. This systematic review critically summarizes the epidemiological evidence regarding 25OHD levels and the risk for colorectal cancer and T2DM. The meta-analytical calculation revealed a pooled relative risk RR of 0.62 CI 0.56–0.70; I2 = 14.7% for colorectal cancer and an RR of 0.66 CI 0.61–0.73; I2 = 38.6% for T2DM when comparing individuals with the highest category of 25OHD with those in the lowest. A dose–response analysis showed an inverse association between 25OHD levels and RR for both outcomes up to concentrations of about 55 ng-mL for colorectal cancer and about 65 ng-mL for T2DM. At still higher 25OHD levels the RR increases slightly, consistent with a U-shaped association. In conclusion, a higher 25OHD status is associated with a lower risk for colorectal cancer and T2DM; however, this advantage is gradually lost as levels increase beyond 50–60 ng-mL. View Full-Text

Keywords: vitamin D; 25-hydroxyvitamin D; colorectal cancer; type 2 diabetes mellitus; systematic review; meta-analysis vitamin D; 25-hydroxyvitamin D; colorectal cancer; type 2 diabetes mellitus; systematic review; meta-analysis





Autor: Cem Ekmekcioglu * , Daniela Haluza and Michael Kundi

Fuente: http://mdpi.com/



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