Transgenic Mouse Studies to Understand the Regulation, Expression and Function of the Testis-Specific Protein Y-Encoded TSPY GeneReportar como inadecuado




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Institute of Human Genetics, Hannover Medical School, D-30625 Hannover, Germany





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Abstract The TSPY gene, which encodes the testis-specific protein, Y-encoded, was first discovered and characterized in humans, but orthologous genes were subsequently identified on the Y chromosome of many other placental mammals. TSPY is expressed in the testis and to a much lesser extent in the prostate gland, and it is assumed that TSPY serves function in spermatogonial proliferation and-or differentiation. It is further supposed that TSPY is involved in male infertility and exerts oncogenic effects in gonadal and prostate tumor formation. As a member of the TSPY-SET-NAP protein family, TSPY is able to bind cyclin B types, and stimulates the cyclin B1-CDK1 kinase activity, thereby accelerating the G2-M phase transition of the cell cycle of target cells. Because the laboratory mouse carries only a nonfunctional Y-chromosomal Tspy-ps pseudogene, a knockout mouse model for functional research analyses is not a feasible approach. In the last decade, three classical transgenic mouse models have been developed to contribute to our understanding of TSPY regulation, expression and function. The different transgenic mouse approaches and their relevance for studying TSPY regulation, expression and function are discussed in this review. View Full-Text

Keywords: testis-specific protein, Y-encoded TSPY; TSPY-like proteins; male meiosis; Gonadoblastoma oncogene; germ cell tumor stem cells; cell cycle regulation; transcription regulation; neural functions; tumor suppressor; sexual dimorphisms testis-specific protein, Y-encoded TSPY; TSPY-like proteins; male meiosis; Gonadoblastoma oncogene; germ cell tumor stem cells; cell cycle regulation; transcription regulation; neural functions; tumor suppressor; sexual dimorphisms





Autor: Stephanie Schubert * and Jörg Schmidtke

Fuente: http://mdpi.com/



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