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A Quasi-Mechanistic Mathematical Representation for Blood Viscosity


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1

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA

2

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Goodarz Ahmadi

Abstract Blood viscosity is a crucial element for any computation of flow fields in the vasculature or blood-wetted devices. Although blood is comprised of multiple elements, and its viscosity can vary widely depending on several factors, in practical applications, it is commonly assumed to be a homogeneous, Newtonian fluid with a nominal viscosity typically of 3.5 cP. Two quasi-mechanistic models for viscosity are presented here, built on the foundation of the Krieger model of suspensions, in which dependencies on shear rate, hematocrit, and plasma protein concentrations are explicitly represented. A 3-parameter Asymptotic Krieger model AKM exhibited excellent agreement with published Couette experiments over four decades of shear rate 0–1000 s-1, root mean square RMS error = 0.21 cP. A 5-parameter Modified Krieger Model MKM5 also demonstrated a very good fit to the data RMS error = 1.74 cP. These models avoid discontinuities exhibited by previous models with respect to hematocrit and shear rate. In summary, the quasi-mechanistic, Modified-Krieger Model presented here offers a reasonable compromise in complexity to provide flexibility to account for several factors that affect viscosity in practical applications, while assuring accuracy and stability. View Full-Text

Keywords: hemorheology; shear thinning; blood viscosity; aggregation; Krieger model hemorheology; shear thinning; blood viscosity; aggregation; Krieger model





Autor: Samuel J. Hund 1, Marina V. Kameneva 2 and James F. Antaki 1,2,*

Fuente: http://mdpi.com/



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