Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the JawReportar como inadecuado




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Department of Oral and Maxillofacial Surgery of the University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131 Mainz, Germany





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Academic Editor: Patrick R. Schmidlin

Abstract To date there is no consensus on the role of diabetes in the development of medication-related osteonecrosis of the jaws MR-ONJ. Therefore, this study aimed to investigate the prevalence of diabetes and pathological glucose metabolism in patients with MR-ONJ compared to the general population. All maxillofacial surgery inpatients in one year at our department were investigated regarding diagnosis, anamnesis, medication, and blood glucose readings. 1374 records were analyzed. 35 patients with MR-ONJ were identified. Diabetics accounted for 14.3%. No significant difference in the prevalence of known diabetes was found, except for pathological glucose metabolism in patients with MR-ONJ p < 0.001. Diabetes does not necessarily promote the onset of MR-ONJ. Therefore, diabetes should not be considered as a standalone risk factor. On the contrary, hyperglycemia as a possible indicator for poorly managed or yet undetected diabetes is associated with MR-ONJ. View Full-Text

Keywords: diabetes; hyperglycemia; bisphosphonates; denosumab; MR-ONJ; BP-ONJ diabetes; hyperglycemia; bisphosphonates; denosumab; MR-ONJ; BP-ONJ





Autor: Roman K. Rahimi-Nedjat * , Keyvan Sagheb, Andreas Pabst, Lukas Olk and Christian Walter

Fuente: http://mdpi.com/



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