Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune ResponseReportar como inadecuado




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Leiden Institute of Advanced Computer Science, Leiden University, Niels Bohrweg 1, 2333CA Leiden, The Netherlands





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Academic Editors: Filippo Castiglione and Paolo Tieri

Abstract Computational and mathematical modeling is important in support of a better understanding of complex behavior in biology. For the investigation of biological systems, researchers have used computers to construct, verify, and validate models that describe the mechanisms behind biological processes in multi-scale representations. In this paper we combine Petri net models that represent the mycobacterial infection process and innate immune response at various levels of organization, from molecular interaction to granuloma dissemination. In addition to the conventional graphical representation of the Petri net, the outcome of the model is projected onto a 3D model representing the zebrafish embryo. In this manner we provide a visualization of the process in a simulation framework that portrays the infection in the living system. View Full-Text

Keywords: immune system modeling; petri net; 3D visualization immune system modeling; petri net; 3D visualization





Autor: Rafael V. Carvalho, Jeroen van den Heuvel, Jetty Kleijn and Fons J. Verbeek *

Fuente: http://mdpi.com/



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