Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical SitesReportar como inadecuado


Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites


Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy

2

Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia





Academic Editor: Samuel C. Mok

Abstract Approximately 200 human papillomaviruses HPVs infect human epithelial cells, of which the alpha and beta types have been the most extensively studied. Alpha HPV types mainly infect mucosal epithelia and a small group of these causes over 600,000 cancers per year worldwide at various anatomical sites, especially anogenital and head-and-neck cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. Beta HPV types infect cutaneous epithelia and may contribute towards the initiation of non-melanoma skin cancers. HPVs encode two oncoproteins, E6 and E7, which are directly responsible for the development of HPV-induced carcinogenesis. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control, of apoptosis and of cell polarity control networks. In this review, the biological consequences of papillomavirus targeting of various cellular substrates at diverse anatomical sites in the development of HPV-induced malignancies are highlighted. View Full-Text

Keywords: HPV; cancer; E6 and E7 oncoproteins HPV; cancer; E6 and E7 oncoproteins





Autor: Vjekoslav Tomaić 1,2

Fuente: http://mdpi.com/



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