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Photodynamic Therapy and Non-Melanoma Skin Cancer


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Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester M6 8HD, UK





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Academic Editor: Michael R. Hamblin

Abstract Non-melanoma skin cancer NMSC is the most common malignancy among the Caucasian population. Photodynamic therapy PDT is gaining popularity for the treatment of basal cell carcinoma BCC, Bowen’s disease BD and actinic keratosis AK. A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX PpIX is produced then activated by the introduction of a light source. Daylight-mediated MAL methyl aminolaevulinate PDT for AKs has the advantage of decreased pain and better patient tolerance. PDT is an effective treatment for superficial BCC, BD and both individual and field treatment of AKs. Excellent cosmesis can be achieved with high patient satisfaction. Variable results have been reported for nodular BCC, with improved outcomes following pretreatment and repeated PDT cycles. The more aggressive basisquamous, morphoeic infiltrating subtypes of BCC and invasive squamous cell carcinoma SCC are not suitable for PDT. Prevention of -field cancerization- in organ transplant recipients on long-term immunosuppression and patients with Gorlin syndrome naevoid basal cell carcinoma syndrome is a promising development. The optimisation of PDT techniques with improved photosensitiser delivery to target tissues, new generation photosensitisers and novel light sources may expand the future role of PDT in NMSC management. View Full-Text

Keywords: photodynamic therapy; non-melanoma skin cancer; basal cell carcinoma; actinic keratosis; field cancerization; organ transplant recipients; Gorlin syndrome photodynamic therapy; non-melanoma skin cancer; basal cell carcinoma; actinic keratosis; field cancerization; organ transplant recipients; Gorlin syndrome





Autor: Liezel L. Griffin and John T. Lear *

Fuente: http://mdpi.com/



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