Androgen Receptor: A Complex Therapeutic Target for Breast CancerReportar como inadecuado


Androgen Receptor: A Complex Therapeutic Target for Breast Cancer


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1

Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA

2

College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Emmanuel S. Antonarakis

Abstract Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor ER and human epidermal growth factor receptor HER2 are the mainstay therapeutic targets in breast cancer, the androgen receptor AR is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR’s therapeutic role in breast cancer. View Full-Text

Keywords: androgen receptor; breast cancer; selective androgen receptor modulator SARM; estrogen receptor; triple-negative breast cancer TNBC androgen receptor; breast cancer; selective androgen receptor modulator SARM; estrogen receptor; triple-negative breast cancer TNBC





Autor: Ramesh Narayanan 1 and James T. Dalton 2,*

Fuente: http://mdpi.com/



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