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Myriam Sánchez ;Biomédica 2004, 24 4

Autor: Wilson Mejía

Fuente: http://www.redalyc.org/


Introducción



Biomédica ISSN: 0120-4157 biomedica@ins.gov.co Instituto Nacional de Salud Colombia Mejía, Wilson; Sánchez, Myriam Protein malnutrition up-regulates growth hormone receptor expression in rat splenic B lymphocytes Biomédica, vol.
24, núm.
4, diciembre, 2004, pp.
403-412 Instituto Nacional de Salud Bogotá, Colombia Available in: http:--www.redalyc.org-articulo.oa?id=84324409 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Biomédica 2004;24:403-12 PROTEIN MALNUTRITION AND GH RECEPTOR ON LYMPHOID CELLS ARTÍCULO ORIGINAL Protein malnutrition up-regulates growth hormone receptor expression in rat splenic B lymphocytes Wilson Mejía-Naranjo 1 2 1,2 , Myriam Sánchez-Gomez1 Laboratorio de Hormonas, Departmento de Química, Universidad Nacional de Colombia, Bogotá, Colombia. Departmento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, Colombia. The reciprocal interaction between the endocrine and immune systems has been the subject of active research during the last decade, and an important body of evidence has accumulated supporting the role of the GH-IGF axis in immune function.
More recently, the GH-IGF axis has been postulated as playing an important role in the modulation of stress conditions, such as catabolic stages, aging-related disorders, immunodeficient aids patients and malnutrition. Whether these effects are exerted through endocrine, autocrine or paracrine mechanisms remains to be determined for different immune cell types and tissues.
The aim of the current study was to define which specific subsets of lymphocytes are the primary targets for GH action. In addition, the regulatory role of stress induced by protein restriction was investigated with respect to the relative distribution o...





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