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Interstitial Photodynamic Therapy—A Focused Review


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1

Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute RPCI, Elm and Carlton Streets, Buffalo, NY 14263, USA

2

Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Michael R. Hamblin

Abstract Multiple clinical studies have shown that interstitial photodynamic therapy I-PDT is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography CT with contrast may be utilized to assess the response. View Full-Text

Keywords: interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning





Autor: Gal Shafirstein 1,* , David Bellnier 1, Emily Oakley 1, Sasheen Hamilton 1, Mary Potasek 2, Karl Beeson 2 and Evgueni Parilov 2

Fuente: http://mdpi.com/



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