Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal CancersReportar como inadecuado


Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers


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1

Department of Medicine and Surgery DMC, University of Insubria, 21100 Varese, Italy

2

Department of Health Sciences, San Paolo Hospital, University of Milan, 20142 Milano, Italy

3

Department of Experimental, Diagnostic and Specialty Medicine DIMES, University of Bologna, 40126 Bologna, Italy





*

Author to whom correspondence should be addressed.



Academic Editor: Chris O’Callaghan

Abstract The tetrasaccharide structures Siaα2,3Galβ1,3Fucα1,4GlcNAc and Siaα2,3Galβ1,4Fucα1,3GlcNAc constitute the epitopes of the carbohydrate antigens sialyl-Lewis a sLea and sialyl-Lewis x sLex, respectively, and are the minimal requirement for selectin binding to their counter-receptors. Interaction of sLex expressed on the cell surface of leucocytes with E-selectin on endothelial cells allows their arrest and promotes their extravasation. Similarly, the rolling of cancer cells ectopically expressing the selectin ligands on endothelial cells is potentially a crucial step favoring the metastatic process. In this review, we focus on the biosynthetic steps giving rise to selectin ligand expression in cell lines and native tissues of gastrointestinal origin, trying to understand whether and how they are deregulated in cancer. We also discuss the use of such molecules in the diagnosis of gastrointestinal cancers, particularly in light of recent data questioning the ability of colon cancers to express sLea and the possible use of circulating sLex in the early detection of pancreatic cancer. Finally, we reviewed the data dealing with the mechanisms that link selectin ligand expression in gastrointestinal cells to cancer malignancy. This promising research field seems to require additional data on native patient tissues to reach more definitive conclusions. View Full-Text

Keywords: carbohydrate antigens; glycosylation; cancer diagnosis; cancer malignancy carbohydrate antigens; glycosylation; cancer diagnosis; cancer malignancy





Autor: Marco Trinchera 1,* , Adele Aronica 2 and Fabio Dall’Olio 3

Fuente: http://mdpi.com/



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