The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse KidneyReportar como inadecuado


The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney


The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Chair of Medical Biochemistry, Medical College, Jagiellonian University, Kopernika 7, Kraków 31-034, Poland





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Academic Editors: Claus Jacob and Gregory Ian Giles

Abstract Diallyl sulfide DAS, diallyl disulfide DADS and diallyl trisulfide DATS are major oil-soluble organosulfur compounds of garlic responsible for most of its pharmacological effects. The present study investigated the influence of repeated intraperitoneally ip administration of DAS, DADS and DATS on the total level of sulfane sulfur, bound sulfur S-sulfhydration and hydrogen sulfide H2S and on the activity of enzymes, which catalyze sulfane sulfur formation and transfer from a donor to an acceptor in the normal mouse kidney, i.e., γ-cystathionase CSE and rhodanese TST. The activity of aldehyde dehydrogenase ALDH, which is a redox-sensitive protein, containing an –SH group in its catalytic center, was also determined. The obtained results indicated that all tested compounds significantly increased the activity of TST. Moreover, DADS and DATS increased the total sulfane sulfur level and CSE activity in the normal mouse kidney. ALDH activity was inhibited in the kidney after DATS administration. The results indicated also that none of the studied allyl sulfides affected the level of bound sulfur or H2S. Thus, it can be concluded that garlic-derived DADS and DATS can be a source of sulfane sulfur for renal cells but they are not connected with persulfide formation. View Full-Text

Keywords: sulfane sulfur; hydrogen sulfide; bound sulfur; allyl sulfides; aldehyde dehydrogenase; kidney sulfane sulfur; hydrogen sulfide; bound sulfur; allyl sulfides; aldehyde dehydrogenase; kidney





Autor: Małgorzata Iciek * , Anna Bilska-Wilkosz, Magdalena Górny, Maria Sokołowska-Jeżewicz and Danuta Kowalczyk-Pachel

Fuente: http://mdpi.com/



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