HO-1 Induction in Cancer Progression: A Matter of Cell AdaptationReportar como inadecuado


HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation


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1

Department of Experimental Medicine, University of Genoa, Via L. B. Alberti 2, Genoa 16132, Italy

2

Bambino Gesù Children’s Hospital, IRCCS, Piazza S. Onofrio 4, Rome 00165, Italy

3

Giannina Gaslini Institute, IRCCS, Via Gerolamo Gaslini 5, Genoa 16147, Italy





*

Author to whom correspondence should be addressed.



Academic Editor: Debasis Mondal

Abstract The upregulation of heme oxygenase-1 HO-1 is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic, and antinflammatory properties of its metabolic products, HO-1 plays a key role in healthy cells in maintaining redox homeostasis and in preventing carcinogenesis. Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed. In this review, we summarize the current literature regarding the pro-tumorigenic role of HO-1 dependent tumor progression as a promising target in anticancer strategy. View Full-Text

Keywords: HO-1; Nrf2; cancer progression; tumor microenvironment; immune-escape; oxidative stress; NK; melanoma; NSCLC; prostate cancer HO-1; Nrf2; cancer progression; tumor microenvironment; immune-escape; oxidative stress; NK; melanoma; NSCLC; prostate cancer





Autor: Mariapaola Nitti 1, Sabrina Piras 1, Umberto M. Marinari 1, Lorenzo Moretta 2, Maria A. Pronzato 1 and Anna Lisa Furfaro 3,*

Fuente: http://mdpi.com/



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