Vol 6: Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium II.Reportar como inadecuado



 Vol 6: Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium II.


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This article is from International Journal of Biomedical Science : IJBS, volume 6.AbstractA simple and sensitive spectrophotometric method was developed for the determination of acetazolamide ACM in pure form and pharmaceutical preparations. The proposed method is based on the complex formation of acetazolamide with Palladium II chloride in acetate buffer pH5.4 and measuring the absorbance at 308 nm. The absorbance- concentration plot was rectilinear over the concentration range of 5-70 μg-ml with a minimum detection limit LOD of 0.98 μg-ml, limit of quantification LOQ of 2.96 μg-ml, and a molar absorptivity ζ=2.7 × 103 L-mol.cm. The factors affecting the absorbance of the formed complex were carefully studied and optimized. The composition of the complex as well as its stability constant was also investigated. The proposed method was applied for the determination of acetazolamide in its tablets and the results obtained were favorably compared with those obtained using the official method. A proposal of the reaction pathway was postulated.



Autor: Walash, M. I.; El-Brashy, A.; El-Enany, N.; Wahba, M. E. K.

Fuente: https://archive.org/







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