Vol 9: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.Reportar como inadecuado



 Vol 9: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.


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This article is from Nutrition & Metabolism, volume 9.AbstractBackground: Despite plausible biological mechanisms, the differential abilities of phylloquinone PK and menaquinones MKn to prevent bone loss remain controversial. The objective of the current study was to compare the effects of PK, menaquinone-4 MK-4 and menaquinone-7 MK-7 on the rate of bone loss in ovariectomized OVX Norway rats. A secondary aim was to compare the effects of vitamin K with those of bisphosphonates BP on bone loss. Methods: Rats n = 96 were randomized to 6 dosing groups n = 16-group; Sham; OVX; OVX + BP 100 μg-kg-100 μg-mL saline sc; OVX + PK; OVX + MK-4; and OVX + MK-7 for 6 wk. Equimolar daily doses of 107 mg PK-kg, 147 mg MK-4-kg, and 201 mg MK-7-kg diet were provided. Results: BP significantly increased bone strength and bone mineral density BMD vs. OVX P 0.05. However, PK, MK-4 or MK-7 did not change bone strength or BMD compared to the OVX group. Whereas supplementation of PK, MK-4 and MK-7 increased serum and tibia concentrations of each respective form, PK concentrations were consistently higher despite equimolar intakes. Conclusion: PK, MK-4, and MK-7 do not appear to prevent bone loss in OVX rats when administered concurrent with adequate intake of other nutrients.



Autor: Fu, Xueyan; Moreines, Judith; Booth, Sarah L

Fuente: https://archive.org/







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