Vol 4: Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections.Reportar como inadecuado



 Vol 4: Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections.


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This article is from Journal of Oral Microbiology, volume 4.AbstractObjective: This study evaluates the presence of virulence factors and antibiotic susceptibility among enterococcal isolates from oral mucosal and deep infections. Methods: Forty-three enterococcal strains from oral mucosal lesions and 18 from deep infections were isolated from 830 samples that were sent during 2 years to Oral Microbiology, University of Gothenburg, for analysis. The 61 strains were identified by 16S rDNA, and characterized by the presence of the virulence genes efa A endocarditis gene, gel E gelatinase gene, ace collagen binding antigen gene, asa aggregation substance gene, cyl A cytolysin activator gene and esp surface adhesin gene, tested for the production of bacteriocins and presence of plasmids. MIC determination was performed using the E-test method against the most commonly used antibiotics in dentistry, for example, penicillin V, amoxicillin and clindamycin. Vancomycin was included in order to detect vancomycin-resistant enterococci VRE strains. Results: Sixty strains were identified as Enterococcus faecalis and one as Enterococcus faecium. All the virulence genes were detected in more than 93.3% efa A and esp of the E. faecalis strains, while the presence of phenotypic characteristics was much lower gelatinase 10% and hemolysin 16.7%. Forty-six strains produced bacteriocins and one to six plasmids were detected in half of the isolates. Conclusions: Enterococcal strains from oral infections had a high virulence capacity, showed bacteriocin production and had numerous plasmids. They were generally susceptible to ampicillins but were resistant to clindamycin, commonly used in dentistry, and no VRE-strain was found.



Autor: Dahlen, Gunnar; Blomqvist, Susanne; Almstahl, Annica; Carlen, Anette

Fuente: https://archive.org/







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