Vol 27: VHL-mediated disruption of Sox9 activity compromises -cell identity and results in diabetes mellitus.Reportar como inadecuado



 Vol 27: VHL-mediated disruption of Sox9 activity compromises -cell identity and results in diabetes mellitus.


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This article is from Genes & Development, volume 27.Abstractβ-Cell dysfunction contributes to diabetes mellitus. Puri et al. show that deletion of the von Hippel-Lindau Vhlh gene is deleterious to canonical β-cell gene expression. Vhlh loss triggers erroneous expression of factors normally active in progenitor cells, including Sox9. β-Cell-specific expression of Sox9 results in diabetes mellitus. This study reveals that perturbed β-cell identity contributes to diabetes mellitus.



Autor: Puri, Sapna; Akiyama, Haruhiko; Hebrok, Matthias

Fuente: https://archive.org/



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