Vol 13: Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs.Reportar como inadecuado



 Vol 13: Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs.


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This article is from BMC Pregnancy and Childbirth, volume 13.AbstractBackground: Past studies suggest that maternal vitamin D intake during pregnancy may protect against child wheeze but studies on asthma are limited. Our objective was to examine the relation between intake of vitamin D in mid-pregnancy and child asthma and allergic rhinitis at 18 months and 7 years. Methods: We examined data from 44,825 women enrolled during pregnancy in the longitudinal Danish National Birth Cohort 1996–2002. We estimated vitamin D intake from diet and supplements based on information from a validated food frequency questionnaire completed in gestational week 25. At 18 months, we evaluated child asthma using data from phone interviews. We assessed asthma and allergic rhinitis by self-report at age 7 and asthma by using records from national registries. Current asthma at age 7 was defined as lifetime asthma diagnosis and wheeze in the past 12 months. We calculated multivariable risk ratios with 95% CIs comparing highest vs. lowest quintile of vitamin D intake in relation to child allergic disease outcomes. Results: The median 5%-95%ile intake of total vitamin D was 11.73.0-19.4 μg-day 68% from supplements. In multivariable analysis, mothers in the highest vs. lowest quintile of total vitamin D intake were less likely to have children classified with current asthma at 7 years Q5 vs. Q1: 0.74, 95% CI: 0.56, 0.96, P = 0.02 and they were less likely to have children admitted to the hospital due to asthma Q5 vs. Q1: 0.80, 95% CI: 0.64, 1.00, P = 0.05. We found no associations with child asthma at 18 months or with allergic rhinitis at 7 years. Conclusions: Our findings suggest a weak inverse relationship between high total vitamin D and asthma outcomes in later, but not early, childhood. The data did not suggest a clear threshold of vitamin D intake above which risk of asthma was reduced.



Autor: Maslova, Ekaterina; Hansen, Susanne; Jensen, Camilla B; Thorne-Lyman, Andrew L; Str?m, Marin; Olsen, Sjurdur F

Fuente: https://archive.org/



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