Vol 9: Variants Identified by Hepatocellular Carcinoma and Chronic Hepatitis B Virus Infection Susceptibility GWAS Associated with Survival in HBV-Related Hepatocellular Carcinoma.Reportar como inadecuado



 Vol 9: Variants Identified by Hepatocellular Carcinoma and Chronic Hepatitis B Virus Infection Susceptibility GWAS Associated with Survival in HBV-Related Hepatocellular Carcinoma.


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This article is from PLoS ONE, volume 9.AbstractRecent genome-wide association studies GWAS have identified several common susceptibility loci associated with the risk of hepatocellular carcinoma HCC or chronic hepatitis B infection CHB. However, the relationship between these genetic variants and survival of patients with hepatitis B virus HBV-related HCC is still unknown. In this study, 22 single nucleotide polymorphisms SNPs were genotyped among 330 HBV-related HCC patients using the MassARRAY system from Sequenom. Cox proportional hazards regression was used to examine the effects of genotype on survival time under an additive model with age, sex, smoking status and clinical stage as covariates. We identified four SNPs on 6p21 rs1419881 TC, rs7453920 GA,rs3997872 GA and rs7768538 TC, and two SNPs on 8p12 rs2275959 CT and rs7821974 CT significantly associated with survival time of HBV-related HCC patients. Our results suggest that HCC or CHB susceptibility loci might also affect the prognosis of patients with HBV-related HCC.



Autor: Li, Cong; Bi, Xinyu; Huang, Ying; Zhao, Jianjun; Li, Zhiyu; Zhou, Jianguo; Zhang, Meng; Huang, Zhen; Zhao, Hong; Cai, Jianqiang

Fuente: https://archive.org/



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