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 Vol 3: Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset.


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This article is from Scientific Reports, volume 3.AbstractLectin-like ox-LDL receptors LOX-1 play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells HUVECs exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.



Autor: Di Rienzo, Carmine; Jacchetti, Emanuela; Cardarelli, Francesco; Bizzarri, Ranieri; Beltram, Fabio; Cecchini, Marco

Fuente: https://archive.org/







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