Vol 8: USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.Reportar como inadecuado



 Vol 8: USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.


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This article is from Diagnostic Pathology, volume 8.AbstractBackground: Ubiquitination is a reversible process of posttranslational protein modification through the action of the family of deubiquitylating enzymes which contain ubiquitin-specific protease 9x USP9X. Recent evidence indicates that USP9X is involved in the progression of various human cancers. The aim was to detect the expression of USP9X in the progression from normal epithelium to invasive esophageal squamous cell cancer ESCC and evaluate the relevance of USP9X expression to the tumor progression and prognosis. Methods: In this study, USP9X immunohistochemical analysis was performed on tissues constructed from ESCC combined with either normal epithelium or adjacent precursor tissues of 102 patients. All analyses were performed by SPSS 13.0 software. Results: We observed that the level of high USP9X expression increased gradually in the transformation from normal epithelium 4.0%, to low grade intraepithelial neoplasia 10.5%, then to high grade intraepithelial neoplasia 28.6%, and finally to invasive ESCC 40.2%. The expression of USP9X was found to be significantly different between the normal mucosa and ESCC P 



Autor: Peng, Jing; Hu, Qian; Liu, Weiping; He, Xiaoli; Cui, Ling; Chen, Xinlian; Yang, Mei; Liu, Hongqian; Wei, Wei; Liu, Shanling; Wang, He

Fuente: https://archive.org/







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