Vol 14: Using an autologistic regression model to identify spatial risk factors and spatial risk patterns of hand, foot and mouth disease HFMD in Mainland China.Reportar como inadecuado



 Vol 14: Using an autologistic regression model to identify spatial risk factors and spatial risk patterns of hand, foot and mouth disease HFMD in Mainland China.


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This article is from BMC Public Health, volume 14.AbstractBackground: There have been large-scale outbreaks of hand, foot and mouth disease HFMD in Mainland China over the last decade. These events varied greatly across the country. It is necessary to identify the spatial risk factors and spatial distribution patterns of HFMD for public health control and prevention. Climate risk factors associated with HFMD occurrence have been recognized. However, few studies discussed the socio-economic determinants of HFMD risk at a space scale. Methods: HFMD records in Mainland China in May 2008 were collected. Both climate and socio-economic factors were selected as potential risk exposures of HFMD. Odds ratio OR was used to identify the spatial risk factors. A spatial autologistic regression model was employed to get OR values of each exposures and model the spatial distribution patterns of HFMD risk. Results: Results showed that both climate and socio-economic variables were spatial risk factors for HFMD transmission in Mainland China. The statistically significant risk factors are monthly average precipitation OR = 1.4354, monthly average temperature OR = 1.379, monthly average wind speed OR = 1.186, the number of industrial enterprises above designated size OR = 17.699, the population density OR = 1.953, and the proportion of student population OR = 1.286. The spatial autologistic regression model has a good goodness of fit ROC = 0.817 and prediction accuracy Correct ratio = 78.45% of HFMD occurrence. The autologistic regression model also reduces the contribution of the residual term in the ordinary logistic regression model significantly, from 17.25 to 1.25 for the odds ratio. Based on the prediction results of the spatial model, we obtained a map of the probability of HFMD occurrence that shows the spatial distribution pattern and local epidemic risk over Mainland China. Conclusions: The autologistic regression model was used to identify spatial risk factors and model spatial risk patterns of HFMD. HFMD occurrences were found to be spatially heterogeneous over the Mainland China, which is related to both the climate and socio-economic variables. The combination of socio-economic and climate exposures can explain the HFMD occurrences more comprehensively and objectively than those with only climate exposures. The modeled probability of HFMD occurrence at the county level reveals not only the spatial trends, but also the local details of epidemic risk, even in the regions where there were no HFMD case records.



Autor: Bo, Yan-Chen; Song, Chao; Wang, Jin-Feng; Li, Xiao-Wen

Fuente: https://archive.org/







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