Vol 9: Uncoupling of Glomerular IgA Deposition and Disease Progression in Alymphoplasia Mice with IgA Nephropathy.Reportar como inadecuado



 Vol 9: Uncoupling of Glomerular IgA Deposition and Disease Progression in Alymphoplasia Mice with IgA Nephropathy.


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This article is from PLoS ONE, volume 9.AbstractPrevious clinical and experimental studies have indicated that cells responsible for IgA nephropathy IgAN, at least in part, are localized in bone marrow BM. Indeed, we have demonstrated that murine IgAN can be experimentally reconstituted by bone marrow transplantation BMT from IgAN prone mice in not only normal mice, but also in alymphoplasia mice aly-aly independent of IgA+ cells homing to mucosa or secondary lymphoid tissues. The objective of the present study was to further assess whether secondary lymph nodes LN contribute to the progression of this disease. BM cells from the several lines of IgAN prone mice were transplanted into aly-aly and wild-type mice B6. Although the transplanted aly-aly showed the same degree of mesangial IgA and IgG deposition and the same serum elevation levels of IgA and IgA-IgG immune-complexes IC as B6, even in extent, the progression of glomerular injury was observed only in B6. This uncoupling in aly-aly was associated with a lack of CD4+ T cells and macrophage infiltration, although phlogogenic capacity to nephritogenic IC of renal resident cells was identical between both recipients. It is suggested that secondary LN may be required for the full progression of IgAN after nephritogenic IgA and IgA-IgG IC deposition.



Autor: Aizawa, Masashi; Suzuki, Yusuke; Suzuki, Hitoshi; Pang, Huihua; Kihara, Masao; Nakata, Junichiro; Yamaji, Kenji; Horikoshi, Satoshi; Tomino, Yasuhiko

Fuente: https://archive.org/







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