Vol 57: The effect of aromatase inhibitor letrozole incorporated in gonadotrophin-releasing hormone antagonist multiple dose protocol in poor responders undergoing in vitro fertilization.Reportar como inadecuado



 Vol 57: The effect of aromatase inhibitor letrozole incorporated in gonadotrophin-releasing hormone antagonist multiple dose protocol in poor responders undergoing in vitro fertilization.


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This article is from Obstetrics & Gynecology Science, volume 57.AbstractObjective: To evaluate whether letrozole incorporated in a gonadotrophin-releasing hormone GnRH antagonist multiple dose protocol MDP improved controlled ovarian stimulation COS and in vitro fertilization IVF results in poor responders who underwent IVF treatment. Methods: In this retrospective cohort study, a total of 103 consecutive IVF cycles that were performed during either the letrozole-GnRH antagonist MDP cycles letrozole group, n=46 or the standard GnRH antagonist MDP cycles control group, n=57 were included in 103 poor responders. COS results and IVF outcomes were compared between the two groups. Results: Total dose and days of recombinant human follicle stimulating hormone rhFSH administered were significantly fewer in the letrozole group than in the control group. Duration of GnRH antagonist administered was also shorter in the letrozole group. The number of oocytes retrieved was significantly higher in the letrozole group. However, clinical pregnancy rate per cycle initiated, clinical pregnancy rate per embryo transfer, embryo implantation rate and miscarriage rate were similar in the two groups. Conclusion: The letrozole incorporated in GnRH antagonist MDP may be more effective because it results comparable pregnancy outcomes with shorter duration and smaller dose of rhFSH, when compared with the standard GnRH antagonist MDP.



Autor: Lee, Kyung-Hee; Kim, Chung-Hoon; Suk, Hye-Jin; Lee, You-Jeong; Kwon, Su-Kyung; Kim, Sung-Hoon; Chae, Hee-Dong; Kang, Byung-Moon

Fuente: https://archive.org/







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