Vol 13: Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents.Reportar como inadecuado



 Vol 13: Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents.


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This article is from Lipids in Health and Disease, volume 13.AbstractBackground: Although the association between the apolipoprotein A5 APOA5 genetic variants and hypertriglyceridemia has been extensively studied, there have been few studies, particularly in children and adolescents, on the association between APOA5 genetic variants and obesity or non-high-density lipoprotein cholesterol non-HDL-C levels. The objective of this study was to examine whether APOA5 gene polymorphisms affect body mass index BMI or plasma non-HDL-C levels in Chinese child population. Methods: This was a case–control study. Single nucleotide polymorphisms SNPs were genotyped using Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry for an association study in 569 obese or overweight and 194 healthy Chinese children and adolescents. Results: Genotype distributions for all polymorphisms in both cohorts were in accordance with the Hardy-Weinberg distribution. The frequencies of the risk alleles in rs662799 and rs651821 SNPs in APOA5 gene were all increased in obese or overweight patients compared to the controls. After adjusted for age and sex, C carriers in rs662799 had a 1.496-fold 95% confidence interval CI: 1.074-2.084, P = 0.017 higher risk for developing obesity or overweight than subjects with TT genotype, while C carriers in rs651821 had a 1.515-fold higher risk than subjects with TT genotype 95% CI: 1.088-2.100, P = 0.014. Triglyceride TG and non-HDL-C concentrations were significantly different among rs662799 variants and both were higher in carriers of minor allele than in noncarriers for TG 1.64 ± 0.96 vs. 1.33 ± 0.67 mmol-L P 



Autor: Zhu, Wei-fen; Wang, Chun-lin; Liang, Li; Shen, Zheng; Fu, Jun-fen; Liu, Pei-ning; Lv, Lan-qiu; Zhu, Yi-min

Fuente: https://archive.org/







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