Vol 10: Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4-SDF-1 expression in vivo.Reportar como inadecuado



 Vol 10: Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4-SDF-1 expression in vivo.


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This article is from Molecular Medicine Reports, volume 10.AbstractThe aim of our study was to elucidate the effect of tacrolimus FK506 and of C-X-C chemokine receptor type 4 CXCR4, which is a receptor specific to the stromal cell-derived factor-1α SDF-1α, on growth and metastasis of hepatocellular carcinoma HCC. Following treatment with different concentrations of FK506, AMD3100 or normal saline NS, the proliferation of Morris rat hepatoma 3924A MH3924A cells was measured by the MTT assay, the expression of CXCR4 was analyzed with immunohistochemistry, and the morphological changes and the invasiveness of cells were studied with a transwell assay and under a scanning electron microscope, respectively. In addition, August Copenhagen Irish rat models implanted with tumor were used to examine the pathological changes and invasiveness of tumor in vivo, the expression of CXCR4 in tumor tissues and the expression of SDF-1α in the adjacent tissues to the HCC ones, using immunohistochemistry. In vitro, FK506 100–1,000 μg-l significantly promoted the proliferation of MH3924A cells P0.05. By contrast, AMD3100 had no effect on the proliferation of MH3924A cells, but significantly reduced the expression of CXCR4 P



Autor: ZHU, HUAQI; SUN, QIMAN; TAN, CHANGJUN; XU, MIN; DAI, ZHI; WANG, ZHENG; FAN, JIA; ZHOU, JIAN

Fuente: https://archive.org/







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