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 Vol 15: The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.


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This article is from BMC Medical Genetics, volume 15.AbstractBackground: Studies suggest that the 9p21-3 locus may influence susceptibility to myocardial infarction. We performed a systematic review and meta-analysis to assess whether this locus is associated with severity of coronary atherosclerosis and adverse clinical outcomes in those with known coronary disease. Methods: Multiple electronic databases were searched from inception through August 2012. Studies examining 9p21-3 genotype in patients with known coronary artery disease were included. We extracted the association of the 9p21-3 locus with measures of severity of coronary atherosclerosis number of diseased vessels, Gensini Score, Duke CAD Prognostic Index DPI, angiographic outcomes change in minimum lumen diameter ∆MLD and number of new lesions at follow-up, and key clinical outcomes all-cause mortality, recurrent myocardial infarction and the need for coronary revascularization. Relative risks RR and weighted mean difference WMD were pooled using the random effects models. Results: 23 cohorts enrolling 16,860 participants were analyzed. There was no significant difference between HR and LR genotypes in terms of all-cause mortality, recurrent myocardial infarction or the frequency of coronary revascularization. HR genotype was associated with increased risk of triple vessel disease RR = 1.34; 95% CI 1.08-1.65; P = 0.01 and increased baseline Gensini Score WMD = 5.30; 95% CI 0.66-9.93; P = 0.03. However there was no association with DPI WMD = 4.00; 95% CI 2.94-10.94; P = 0.26. HR genotype did not predict ∆MLD or number of new lesions at follow-up. Conclusions: Patients of coronary atherosclerosis who carry the high risk genotype of the 9p21-3 allele may be more likely to have multi-vessel CAD. However the effect of this allele on CAD progression and disease specific clinical outcomes are not observed possibly due to diminishing genetic risk following dietary modification and therapy.



Autor: Munir, Muhammad S; Wang, Zhen; Alahdab, Fares; Steffen, Mark W; Erwin, Patricia J; Kullo, Iftikhar J; Murad, Mohammad Hassan

Fuente: https://archive.org/



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