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 Vol 5: The Emergence of Bacterial Hopeful Monsters.


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This article is from mBio, volume 5.AbstractThe global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type ST 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important β-lactams. In their recent mBio article, Chen et al. mBio 53:e01355-14 described how ST258 emerged through -hybridization- between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria.



Autor: Croucher, Nicholas J.; Klugman, Keith P.

Fuente: https://archive.org/







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