Vol 14: Study protocol: mnster tinnitus randomized controlled clinical trial-2013 based on tailor-made notched music training TMNMT.Reportar como inadecuado



 Vol 14: Study protocol: mnster tinnitus randomized controlled clinical trial-2013 based on tailor-made notched music training TMNMT.


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This article is from BMC Neurology, volume 14.AbstractBackground: Tinnitus is a result of hyper-activity-hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize around tonotopic regions coding the tinnitus frequency. Based on this assumption a novel treatment for tonal tinnitus - tailor-made notched music training TMNMT Proc Natl Acad Sci USA 107:1207–1210, 2010; Ann N Y Acad Sci 1252:253–258, 2012; Frontiers Syst Neurosci 6:50, 2012 has been introduced and will be tested in this clinical trial on a large number of tinnitus patients. Methods and design: A randomized controlled trial RCT in parallel group design will be performed in a double-blinded manner. The choice of the intervention we are going to apply is based on two -proof of concept- studies in humans Proc Natl Acad Sci USA 107:1207–1210, 2010; Ann N Y Acad Sci 1252:253–258, 2012; Frontiers Syst Neurosci 6:50, 2012; PloS One 69:e24685, 2011 and on a recent animal study Front Syst Neurosci 7:21, 2013.The RCT includes 100 participants with chronic, tonal tinnitus who listened to tailor-made notched music TMNM for two hours a day for three months. The effect of TMNMT is assessed by the tinnitus handicap questionnaire and visual analogue scales VAS measuring perceived tinnitus loudness, distress and handicap. Discussion: This is the first randomized controlled trial applying TMNMT on a larger number of patients with tonal tinnitus. Our data will verify more securely and reliably the effectiveness of this kind of completely non-invasive and low-cost treatment approach on tonal tinnitus. Trial registration: Current Controlled Trials ISRCTN04840953



Autor: Pantev, Christo; Rudack, Claudia; Stein, Alwina; Wunderlich, Robert; Engell, Alva; Lau, Pia; Wollbrink, Andreas; Shaykevich, Alex

Fuente: https://archive.org/







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