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 Vol 3: Significant SNPs have limited prediction ability for thyroid cancer.


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This article is from Cancer Medicine, volume 3.AbstractRecently, five thyroid cancer significantly associated genetic variants rs965513, rs944289, rs116909374, rs966423, and rs2439302 have been discovered and validated in two independent GWAS and numerous case–control studies, which were conducted in different populations. We genotyped the above five single nucleotide polymorphisms SNPs in Han Chinese populations and performed thyroid cancer-risk predictions with nine machine learning methods. We found that four SNPs were significantly associated with thyroid cancer in Han Chinese population, while no polymorphism was observed for rs116909374. Small familial relative risks 1.02–1.05 and limited power to predict thyroid cancer AUCs: 0.54–0.60 indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer.



Autor: Guo, Shicheng; Wang, Yu-Long; Li, Yi; Jin, Li; Xiong, Momiao; Ji, Qing-Hai; Wang, Jiucun

Fuente: https://archive.org/







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